2.two]decane Main and defining the geometry of the exocyclic double bond. The activation energies of formation on the vinyl-gold intermediates were calculated and discovered a silyl enol ether using an unprotected indole moiety as an appropriate precursor for the Toste cyclization. This 6-move synthesis didn't include any nonstrategic redox manipulations.

The initial asymmetric full synthesis of conolidine was designed by Micalizio and coworkers in 2011.[two] This synthetic route will allow access to possibly enantiomer (mirror picture) of conolidine by means of an early enzymatic resolution.

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